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Exact(4)
Together, these results demonstrate that CUL3Δ403 459 maintains interactions and basic functionality critical for CRL activity.
Yet the R2 group still maintains interactions with Arg340 in one of two observed alternate conformations for this residue.
Despite the negative charge conferred by its highly phosphorylated state, Rap1 maintains interactions with its binding partners.
Because the CrPV-IRES maintains interactions with each subunit in both states, the rotation of the subunits results in a somewhat different orientation and conformation for the CrPV-IRES in the two states.
Similar(56)
With this approach, we expected to maintain interactions important for protein stability while directing the introduction of variability to areas important for catalysis.
During the MD simulation, the three inhibitor molecules fluctuated at the respective binding sites at different amplitudes, while all of the molecules maintained interactions with the protein.
Additionally, differences in their capacities to establish and maintain interactions with residues such as Asp93, Gly95, Thr133, Asp289, Gly291, and Asn294 during this step allow differentiation among the inhibitory activities of the HEAs.
Second, for Tetherin to work, it has to maintain interactions with conserved elements of the cellular trafficking and endocytosis machinery.
This showed that the Co-IP experimental conditions were gentle enough to maintain interactions.
In other words, while there is a strong selective pressure to maintain interactions within a module, there is less pressure to maintain between-module interactions.
Since, physiologically, fibroblasts maintain interactions with the tumor cells, the fibroblast co-culture assays were used for further analysis.
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