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These data suggest a prevalent role for stabilizing selection that maintains gene expression levels.
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Finally, in vivo experiments showed that the biodegradable HES markedly reduced the non-specific lung transcription of the polyplexes, but maintained gene expression in the tumor, contrary to the non-degradable HES and PEG controls, which reduced both tumor and lung expression.
Polycomb group (PcG) proteins are essential to maintain gene expression patterns during development.
Polycomb group (PcG) proteins maintain gene expression patterns during development in animals and plants by establishing a cellular memory system for transcriptional repression [1].
In general, therefore, the data showed that p56Lck, and thus the TCR signal, is more important for maintaining gene expression than for repressing it.
In order to favour biologically maintained gene expression changes, we filtered the data to identify genes that were significantly regulated (p≤0.05) in each of the two cohorts, rather than relying on overall statistical significance in the study.
As described below, we expect that weak selection to maintain gene expression stability may result in positive selection on certain compensatory regulatory changes in spite of the fact that most novel alleles are likely to be deleterious.
Fsh is a Trithorax group protein, whose main action is to maintain gene expression.
DNA methylation is a normal procedure to maintain gene expression with normal patterns in mammalian cells.
Epigenetic regulation is necessary for maintaining gene expression patterns in multicellular organisms.
How and to which extent chromatin modulators interact to maintain gene expression states remains largely unexplored.
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