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To reduce the treatment time and ensure accurate dose delivery to moving targets, the number of intensity levels was minimized while maintaining dose coverage to PTV and minimizing dose to organs at risk (OARs).
To test whether reducing radiation dose to uninvolved bladder while maintaining dose to the tumor would reduce side effects without impairing local control in the treatment of muscle-invasive bladder cancer.
To reach steady-state levels of the antibody in question an initial dose of twice the maintaining dose was given 4 to 24 hours before wounding.
Growth factors were not allowed to maintain dose intensity.
Growth factor support to maintain dose intensity was administered to 16 patients (73%).
These results confirm the importance of tolerable treatment and maintaining dose intensity.
The prophylactic use of G-CSF to maintain dose intensity was not permitted.
The use of growth factors to maintain dose was not permitted.
Improved dose individualization and avoidance of or reduction in the severity of toxicity would assist in maintaining dose intensity.
A recent review underscored the importance of maintaining dose levels sufficiently above coverage levels for serum A10-receptors [ 7].
The results reported here indicate the feasibility of this concept by using a sequential approach to maintain dose intensity.
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CEO of Professional Science Editing for Scientists @ prosciediting.com