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Kohsaka, A. et al. The circadian clock maintains cardiac function by regulating mitochondrial metabolism in mice.
Cardiac remodeling, whether through anabolic or catabolic processes, initially improves or maintains cardiac function.
These findings suggest that therapeutic inhibition of MK2 after acute MI, using rationally-designed cell-permeant peptides, inhibits cardiac fibrosis and maintains cardiac function by mechanisms that involve inhibiting cardiomyocyte apoptosis, while enhancing primary cardiac fibroblast cell death.
For example, IGF-IR enhances neuronal survival, maintains cardiac function, stimulates bone formation and hematopoiesis (Zumkeller, 2002; Rosen, 2004; Leinninger and Feldman, 2005; Saetrum Opgaard and Wang, 2005).
This hypothesis is supported by the observation of Gebauer et al. that LV apical pacing, compared with other sites, preserves septal to lateral LV synchrony and systolic function [ 56], as well as by other studies showing that LV apical pacing maintains cardiac function at a normal level [ 17, 50].
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Giordano, F.J. et al. A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function.
To treat hypothermia in patients with a maintained cardiac function, a "low stress strategy" is first recommended.
Coronary blood flow is important for maintaining cardiac function, and neovascular formation is necessary to compensate for the increased oxygen demand of hypertrophic heart as well as developmental heart1.
For successful treatment of myocardial infarction (MI), it is important to prevent cardiac fibrosis and maintain cardiac function by protecting cardiomyocytes and inducing angiogenesis.
A number of recent studies point to SIRT5 desuccinylase activity being important in maintaining cardiac function and metabolism under stress.
As adrenergic stimulation is important in maintaining cardiac function in the perinatal period, alterations of thyroid status during this period can be expected to result in abnormal reactivity and increased perinatal risk.
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