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These results indicate that Trx maintains a type II neuroblast functional identity by regulating the transcription of specific target genes.
These data strongly suggest that Trx maintains a type II neuroblast functional identity by regulating H3K4 methylation in specific downstream target loci.
4) The reviewers strongly recommend deleting the discussion section on "Trx maintains a type II neuroblast functional identity independently of the Polycomb protein".
If Trx maintains a type II neuroblast functional identity by regulating btd transcription, removing btd function should trigger type II neuroblasts to adopt a type I neuroblast functional identity.
Together, these data strongly support our hypothesis that Trx maintains a type II neuroblast functional identity through the SET1/MLL complex via a mechanism dependent of the histone methyltransferase activity.
DOI: http://dx.doi.org/10.7554/eLife.03502.009 We focus on the Rbbp5 protein, which is essential for eliciting the histone methyltransferase activity of the SET1/MLL complex (Cao et al., 2010), to test whether Trx maintains a type II neuroblast functional identity through the SET1/MLL complex.
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On the one hand the Zhuocang Tibetans have an extremely open attitude towards different cultures, yet, on the other, they scrupulously adhere to their own core culture, maintaining a type of attitude that sets boundaries without closing doors.
We can maintain a type of open mindedness that does not risk casting us into willful ignorance.
The expression patterns of these proteins are shown in Figure 5. Detection of EBNA-1, LMP-1 and EBNA-3 proteins clearly showed that the recombinant GFP-EBV was capable of transforming primary B-cells into LCLs and was also able to maintain a type III latency program.
Thus, we conclude that trx regulates neuroblast heterogeneity by maintaining a type II neuroblast functional identity.
These data strongly suggest that Trx regulates neuroblast heterogeneity by maintaining a type II neuroblast identity.
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