Sentence examples for maintains a stem from inspiring English sources

However, other studies have indicated that CXCR4 is highly expressed on cancer stem cells, and its activation maintains a stem cell population in tamoxifen-resistant breast cancer [ 29].

Thus, the basal cell expresses only Pax7, maintains a stem cell identity, and functions as a stem cell reservoir, whereas the cell that loses contact with the basal lamina commits to a myogenic fate and has a different profile, expressing both Pax7 and Myf5 [ 111].

Yeung et al. used 3D cell culture to demonstrate that hypoxia inhibits differentiation of colon cancer cells and maintains a stem-like phenotype [ 63].

Sox1, Sox2 or Sox3 maintain a stem cell-like state [49], [50], and Sox9 alters the potential of stem cells from neurogenic to gliogenic [51], whereas Sox10 is essential for terminal oligodendrocyte differentiation [52].

Upregulation of EZH2 expression in tumors appears to correlate with disease progression by maintaining a stem cell-like phenotype.

Asymmetric cell divisions are a major route for stem cells to give rise to differentiated cells while simultaneously maintaining a stem cell population.

This expression pattern is consistent with reported roles for Wnt signaling in maintaining a stem cell pool and in Paneth cell differentiation.

Stem cells are capable of renewing themselves to maintain a stem cell pool as a preserved cell source for tissue homeostasis, while they can also differentiate into mature cells to carry out the function of a specific tissue.

These data demonstrate that GSCs are capable of utilizing different modes of cell division to maintain a stem cell population and GSCs are maintained mainly by symmetric, not by asymmetric cell divisions.

As in conditions favoring proliferation FasL induces ERK1/2 activation, and BM MSCs maintain a stem cell phenotype through ERK1/2-dependent mechanisms, we explored ERK1/2 activation in BM MSCs treated with 0.5 ng/ml FasL.

It is possible that these observations reflect a decreased ratio of muscularis mucosa to epithelium in benign lesions, but a tendency for malignancies to acquire their own Gremlin expression and perhaps a mesenchyme-like phenotype in order to maintain a stem cell-like state independent of the surrounding tissues.