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Recent work has suggested that the brain maintains a physiological range of superoxide production that is required for normal nervous system function.
The powerful, ATP-fueled plasma membrane Ca2+ pump maintains a physiological pump-leak balance with an intracellular Ca2+ concentration in the 20 50 nM range [27], well below Gardos channel activation.
Thus a dynamic equilibrium between synthesis and degradation of the pulmonary ECM maintains a physiological balance [ 87].
Collectively, the study supports the concept that the intestinal epithelium maintains a physiological state of inflammation with respect to continuous microbial exposure, which serves to maintain a tight intestinal barrier, without engendering overt inflammatory responses that would compromise barrier function.
Overall, the data are consistent with the hypothesis that the intestinal epithelium maintains a physiological state of inflammation, due to continuous microbial exposure, that results in a tight intestinal barrier, which serves to minimize antigen translocation to the lamina propria and unwarranted inflammatory responses to mutualistic microbes.
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Biomimicry of the structural features of bone, specifically its macro-to-mesoporosity, may enable the bone cells to osteointegrate, attain and maintain a physiological strain level.
Magnesium ions are essential and highly biocompatible; hydroxide ions are thought to be buffered to maintain a physiological pH while excessive hydrogen evolution can lead to air pockets in the tissue.
Despite this, difficulty in accurately determining the appropriate O2 level(s) in which to culture cells, coupled with a lack of the technology to replicate and maintain a physiological O2 environment in vitro, has hindered addressing this issue.
The lumbar lordosis brace has been designed to meet these requirements and acts as a reminder to the patient to maintain a physiological lumbar lordosis curvature since it comprises a vertical panel on the chest and a curved rigid shell at the back.
Bergmann glial processes ensheathe synapses on Purkinje cells, and play a supportive role in normal transmission by maintaining a physiological synaptic microenvironment.
Furthermore, the 40% glutathione observed may also be enough to maintain a physiological redox environment in cells, i.e. most proteins are still in reduced state.
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