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The main function of DCs is to induce T-cell activation, polarization and expansion against invading pathogens while maintaining tolerance to self antigens (Steinman, 2007).
Indeed, negative signalling by CD5 and CD22 in maintaining tolerance through recruitment of src-homology two domain-containing protein tyrosine phosphatase-1 has also been documented.
Indeed, negative signaling by CD5 and other molecules, such as CD22, in maintaining tolerance through recruitment of src-homology two domain-containing protein tyrosine phosphatase-1 (SHP-1) has also been documented.
Transgenic animal models have demonstrated that sensitivity of B cells to Ag receptor cross-linking correlates to autoimmunity: negative signaling by CD5 and CD22 in maintaining tolerance through recruitment of phosphatase has thus been documented.
The discovery of murine PDCs will allow for the design of models to study viral immunobiology in vivo and to determine their function in various diseases that involve plasmacytoid dendritic cells, such as selected leukemias, lymphomas, allergies, different autoimmune conditions, and their possible role in inducing and maintaining tolerance.
Maintaining tolerance within her craft is significant to how the artist completes her media.
Similar(24)
Maintaining tolerances in the engine and transmission was all but impossible — a perfect recipe for building undependable motorcycles.
Design for manufacturing and assembly guidelines are provided for assembling, fastening, and maintaining tolerances for multiple component designs.
Communication between different immune cells of the intestinal mucosa acts as a rheostat that maintains tolerance to gut microbes.
Regulatory T (Treg) cells establish and maintain tolerance to self-antigens and many foreign antigens, such as allergens, by suppressing effector T-cell proliferation and function.
Repeated exposition to benign and tolerated pathogens leads to the production of regulatory T cells, which helps to maintain tolerance.
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