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Intercellular adhesions share the complex task of establishing and maintaining tissue architecture while allowing tissue growth, renewal and repair.
We conclude that planarian muscle acts as a connective tissue for maintaining tissue architecture through ECM secretion, suggesting functional similarities between cells associated with adult patterning information in vertebrates and planarians.
In epithelial tissues, several classes of proteins are involved in maintaining tissue architecture, including those that promote cell cell adhesion, and others, which mediate cell matrix interactions.
These results confirm the role of these proteins in maintaining tissue architecture and in inhibiting cell invasiveness and potentially indicate the oncogenic potential of the Wnt/β-catenin transduction pathway in feline mammary tumours.
Transforming growth factor-β (TGF-β) initially acts as a tumour suppressor in the process of oncogenesis by inhibiting cell proliferation, maintaining tissue architecture, decreasing genomic instability and inducing cell arrest and apoptosis [ 5– 7].
We argue that the ECM, in the context of IBD, is not only a static scaffold holding cells in place and maintaining tissue architecture but a dynamic participant in intestinal immune responses capable of determining cell fate.
Similar(51)
ALCAM is localized at intercellular junctions in epithelium presumably as part of the adhesive complex that maintains tissue architecture.
Investigation of host-environment interactions in the gut would benefit from a culture system that maintained tissue architecture yet allowed tight experimental control.
These data demonstrate that primary human prostate xenografts, benign and malignant, can be established routinely from human prostate tissue surgical specimens, and that the xenografts maintain tissue architecture and expression of key prostatic markers.
In the central nervous system, the junctional types that establish and maintain tissue architecture include gap junctions, for cytoplasmic connectivity, and tight junctions, for paracellular and/or cell polarity barriers.
The regulation of epithelial cell-cell adhesion is of utmost importance to maintain tissue architecture and to prevent cell invasion during pathological conditions [19], [54], and E-cadherin is a primordial factor often repressed during transition from adenoma to carcinoma [20], [55].
More suggestions(15)
maintaining tissue regulation
maintaining tissue metabolism
maintaining tissue homeostasis
maintaining tissue homoeostasis
maintaining tissue colonization
maintaining tissue perfusion
maintaining tissue polarity
maintaining niche architecture
maintaining tissue coaptation
maintaining tissue approximation
maintaining tissue organization
maintaining chromosome architecture
maintaining tissue integrity
maintaining tissue viability
maintaining tissue moisture
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