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However, it may also reflect a lack of effective pressure for maintaining these genes over long term evolution [24].
By maintaining these genes in a cluster, combinatorial regulatory elements can efficiently coordinate their regulation.
Selection against duplicates may be maintaining these genes as single copy, and therefore are precious markers for comparative genetic and physical mapping, and also for phylogenetic analyses [ 74].
The elevated rate of unidirectional host-to- parasite gene transfer raises the possibility that HGTs may provide a fitness benefit to Rafflesia for maintaining these genes.
Subsequently, the nutrient-rich environments provided by the eukaryotic hosts reduced the selective pressure for maintaining these genes in the genome and allowed parallel gene losses in most SEM lineages.
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When did these clusters form and what are the evolutionary forces that act to maintain these genes clustered?
Thus it is conceivable that the class I HDAC activity contained within the NuRD complex normally serves to maintain these genes in a hypoacetylated state, directing (or allowing) both PRC2 and DNA methyltransferase activity to act upon these target promoters.
The proportion of C. elegans TF genes with detectable orthologs in C. briggsae (713/995, 71.7%) is significantly higher compared to the proportion of all conserved genes between the two species (12858/20621, 62.4%) [ 13] (χ2 = 7.56, df = 1, p = 6.0 × 10-3), which may indicate strong selective pressure to maintain these genes.
Hofacre agrees, saying, "Usage in humans by medical doctors may be the greatest selection pressure for maintaining these resistance genes in humans".
This suggests that not only the mere presence of H3-K27me3, but presence of high levels of H3-K27me3 is crucial for maintaining these PcG target genes in the repressed state.
Like with sickle cell, evidence suggests that natural selection has maintained these disease genes because they too confer resistance to malaria [ 14, 15].
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