Sentence examples for maintaining the specificity from inspiring English sources
An ideal antibody humanization should be capable of maintaining the specificity and affinity toward the antigen and reduces the immunogenicity as much as possible.
This mechanism could participate to maintaining the specificity of olfactory communication in a noisy environment, e.g. when males have to detect minute amounts of sex pheromone in a high background of various plant volatiles.
Overall, the MAPK signaling data indicate that many SYNZIPs can interact in a cytosolic environment, with low to moderate expression levels, while maintaining the specificity of the interactions.
Our pilot evaluation showed that CO outperforms BM25 in terms of sensitivity (65% vs. 38%) by 71% on average, while maintaining the specificity (64% vs. 61%).
In this way, negative auto-regulation may help to increase the input dynamic-range while maintaining the specificity of cooperative regulatory systems.
Therefore, it appears that the leading role in maintaining the specificity of tRNA aminoacylation must, at some point, have passed from the acceptor stem to the anticodon and then, after the genetic code established its complementary core, must have returned back to the acceptor stem (accompanied by the r-aaRS → p-aaRS transition).
In our hands, use of the new EO criteria for diagnosis of CM increases the sensitivity and maintains the specificity of decision making, and therefore should be adopted in CM management practice.
Thus, the Hpx domain in the C-terminal region maintains the specificity of collagenase family MMPs by affecting the substrate binding [2].
Some of the key questions in understanding the ecology and evolution of mutualisms are what factors maintain the specificity and stability of mutualist pairings (e.g., [4] [7]).
Although the generalizability of the observations with mAb 18b7 and chAb 18B7 to other chimeric Abs is unknown, our findings suggest caution with assuming that simply replacing the C region domain maintains the specificity and affinity of the V region.
Given that the murine mAb 18B7 has undergone clinical testing and that has been extensively studied in the laboratory, one approach was to generate chAbs as potential therapeutic reagents, with the assumption that expression of mAb 18B7 V regions in combination with human C regions would maintain the specificity and affinity of the murine mAb.
