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Maintaining the serum concentration above the MIC for 60% of the dosing interval or a 24 hour Area under the concentration curve/MIC ratio of greater than 25 have been suggested as a target pharmacokinetic index [60].
Consequently, controlling and maintaining the serum K+ level within a safe range have great importance in the clinical setting.
FcRn-mediated pathways are important in maintaining the serum retention of native and infused IgG preparations [ 42].
Naturally, β2m is shed into the serum and degraded by the kidneys, maintaining the serum β2m concentrations at 0.09 0.17 μM in healthy individuals [6].
This is achieved by maintaining the serum urate level (SUA) below the saturation point for monosodium urate, and the target level recommended is <357 µmol/L (<6 mg/dL).
The target of the hormonal dysregulation is centered on maintaining the serum calcium and phosphate concentrations in what we think is a normal target range well into the advanced stages of CKD.
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The dose that maintained the serum 25-hydroxyvitamin D3 level >30 μg/l was used.
The clinical principle of the sodium glycerophosphate injection was to maintain the serum phosphorus level at normal standard.
Some also require potassium salts and/or anti-aldosterone medications to correct and maintain the serum potassium level [ 2].
These observations suggest that in concert with LIF/STAT3 signaling, GSK3 inhibition maintains the serum- and feeder-free B6 ES cells in a pluripotent state.
Tegafur is a pro-drug of 5-fluorouracil (5-FU), gimeracil is an inhibitor of dihydropyrimidine dehydrogenase (DPD) which maintains the serum 5-FU level.
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