Sentence examples for maintaining the malignant from inspiring English sources

To better understand its role in maintaining the malignant phenotype, we used RNA interference (RNAi) directed against Rab25 in our study.

Hsp90 plays a key role in regulating the physiology of cells exposed to environmental stress and in maintaining the malignant phenotype of tumor cells.

On the other hand, although exogenous expression of AEG-1 could increase both AURKA and Akt expression levels the simultaneous use of AURKA inhibitor Tozasertib blocked AEG-1's role of up-regulation of Akt expression in ECV304 cells, suggesting that AURKA might be a key mediator of AEG-1 in regulating Akt activation, and a key effector of AEG-1 in maintaining the malignant state of AML.

Expression of specific viral oncoproteins, E6 and E7, is required for maintaining the malignant growth of cervical cancer cells [23].

The lack of regulation of CDKs by its inappropriate activation is essential for maintaining the malignant transformation.

These results suggest that PRL-3 plays a critical role in ovarian cancer tumorigenicity and maintaining the malignant phenotype.

However, the most important question as to whether HPV initiates and maintains the malignant conversion and whether repression of these oncogenes would reverse the malignant phenotype and cause growth arrest have not been answered.

Similarly, osteopontin levels were higher in the serum of patients with CML and contributed to maintain the malignant clones at extramedullary sites (Jamieson et al., 2004a, b).

These data suggest that G9a as well as SUV39H1 are required to maintain the malignant phenotype and could be valid therapeutic targets in human neoplasia.

It is increasingly evident that the UPR has a major role in cancer, where it is required to maintain the malignant phenotype and to develop resistance to chemotherapy [13].

Besides, their continued expression is required to maintain the malignant phenotype [ 6- 8].