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We then prune modules that do not participate in edges (while maintaining the ancestral relationships between the remaining modules).
The Duplication-Degeneration-Complementation (ddc) sub-functionalization model, first proposed by Force et al.[ 18], posits that the paralogs evolve complementary sub-functions, overall maintaining the ancestral function [ 19].
This also suggests that natural selection has the patrolling ability to differentiate between the ancestral and derived locus and potentially purge deleterious mutations that accumulate in the ancestral paralog in charge of maintaining the ancestral function.
Because the two paralogs were expected to be functionally identical under Ohno's model [ 14], either copy could take on the role of maintaining the ancestral function, freeing the other redundant copy to embark on a novel evolutionary trajectory [ 1].
Their conclusions are in agreement with ours, showing that the expression of duplicate genes tends to evolve asymmetrically, one copy maintaining the ancestral expression profile while the others evolve rapidly.
At the molecular level, duplicate genes provide genetic redundancy that could release one or both gene copies from purifying selection, allowing evolutionary changes to occur while maintaining the ancestral protein function.
Similar(53)
Ferns can be considered as an outgroup of the plant kingdom as they maintained the ancestral condition and show different characteristics compared to seed plants.
Indeed, concerted evolution in basal Proserpinus species appears to maintain the ancestral coloration (green and red) despite a wide environmental range (climate and latitude).
One of the subspecies has apparently maintained the ancestral ecology of the species, however.
One subspecies, P. d. bactrianus, residing in Central Asia, has apparently maintained the ancestral ecology, however.
The remaining six modified genomes maintain the ancestral vertebrate gene order, but are larger than 19 kb in size.
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