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Among the 5 Trp residues, W208 was the most crucial in maintaining structural conformation and thermal stability of the enzyme.
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Considering the stability issues sufficient efforts were made to maintain structural conformation of human insulin in microspheres by selecting right excipients and their levels in inner aqueous phase of microspheres.
This indicates the existence of stronger selective pressure to maintain the structural conformation of the parts of the OR related to ligand binding (TM 3, TM5 and EC3 [ 9]) than to maintain the structure of the part of the protein involved in signal transduction and processing.
The main function of HSP60 is to assist protein folding and maintain the structural conformation [ 41, 42].
Since glucosides are non-transportable [ 43] they could "trap" themselves in the active site to maintain the structural conformation similar to SGTP1 in Fig. 8 – i.e., the glucose-bound, occluded conformation of XylE.
Av1-mod has an expanded conformation (increased hydrodynamic radius) that maintains structural integrity.
Enzymes maintain their structural conformations through intramolecular interactions among amino acids and between amino acid and surrounding water molecules.
The standard calibrator origin and structural conformation were shown crucial to achieve accurate quantification.
However, the structural conformation (all B-type) of the oligoduplexes (aps) was determined using CD.
All purified tetrameric MCAD variants revealed alterations of structural conformation, yet of various degrees.
On the other hand, invariant peptides perhaps contribute to structural conformation [ 61].
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