The study using PCR arrays for genes involved in participating stem cell signaling pathways revealed remarkable down regulation of gene expressions in the important genes for maintaining stem cell stemness, self-renewal and proliferation.
In recent years, increasing evidences suggest that telomere length represents another important internal factor in maintaining stem cell pluripotency.
In recent years, it has become clear that mechanical cues play an integral role in maintaining stem cell functions.
Maintaining stem cell features of dermal papilla cells is a critical biological process that keeps the high rate of hair growth.
In adults, there is evidence that the pathway plays a role in maintaining stem cell populations in the stomach and directing epithelial cell differentiation in the intestine.
These results highlight the importance of DNA methylation in maintaining stem cell homeostasis during the development and regeneration of ectodermal organs.
These include a multitude of distinct functions, such as maintaining stem cell homeostasis, promoting fibrosis, immune modulating, as a tumor suppressor and paradoxically, as a tumor progressor.
(2012) develop a culture method that overcomes current limitations in ex vivo hematopoietic stem/progenitor cell expansion by continuously diluting inhibitory signaling factors and maintaining stem cell density.
Hypoxia, an important feature of MSC niche, has been proved to play an important role in maintaining stem cell fate, self-renewal, and multi-potency during the last decade.
Mediated through its regulatory roles in AMPK and mTORC1 pathways as well as gene expression, SIRT1 modulate the activities of genes maintaining stem cell functions and delays cellular senescence.
In mammals, homologs of these proteins are important for maintaining stem cell pluripotency and the identity of differentiated cells [19].
