Sentence examples for maintaining resistant from inspiring English sources

The dosing regimen of AZCQ, containing 3 g azithromycin (1 g daily for 3 days), may possibly be counterselective and curb wild-type pneumococci survival; evidence from a 10-year multinational surveillance study shows that the treatment of respiratory tract infections to the point of bacterial eradication minimizes the potential for selecting and maintaining resistant strains [ 123].

If alleles conferring resistance to infection reduce the fitness of uninfected individuals, it is possible that balancing selection will maintain resistant and susceptible alleles as if they both conferred resistance to specific pathogens [4], [6].

In accordance with this view, such R genes are characterized by high variability in the LRR-coding regions and population genetic analysis indicates that balanced selection acts to maintain resistant and susceptible alleles [ 81- 86].

This confirms that these mosquitoes differ substantially in their capacity to maintain resistant individuals in the population and that these differences are consistent with the cost of resistance and infection now identified between these two species.

All hygromycin B resistant colonies selected maintained resistance to hygromycin during five rounds of subculturing on selective or non-selective agar.

We used a molecular approach to knock down specific targeted proteins in the PI3K signaling pathway to determine the functional role of PI3K in maintaining the resistant phenotype.

However, white clover productivity can be reduced by diseases and pests such as Sitona lepidus (clover root weevil; CRW), and, to maintain productivity, resistant or tolerant germplasm needs to be developed.

Additionally, STAT3 activity is enhanced in paclitaxel-resistant ovarian carcinoma cells to maintain the resistant state of the cells [ 67].

The fact that knockdown of IFNα dramatically reduced IFITM1 expression in the resistant cells and its loss significantly induced cell death highlights the potential dependency of the resistant cells on elevated IFNα to maintain their resistant phenotype and to drive the constitutive overexpression of IFITM1 and the other ISGs in the cells.

We show that activation of autophagy promotes apoptosis in vorinostat-treated U937 parental cells, while even greater activation of autophagy in vorinostat-resistant clones is necessary to protect the cells from apoptosis and maintain the resistant phenotype.

A basic assumption of this strategy is that resistant clones have a lower fitness than sensitive clones because they commit more resources to maintain the resistant phenotype.