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We then bootstrapped a null distribution, by randomizing the CGH regions (within their original chromosome and maintaining region size), by selecting a random CGH probe as the new starting point.
Substantial differences in DNA methylation signatures have been found across different brain regions, highlighting a role for DNA methylation in establishing and maintaining region specific gene expression profiles., Aging has been shown to influence the levels of total DNA methylation as well as methylation at specific genes in a variety of tissues including brain.
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The distinct topographic Hox expression patterns observed in vascular smooth muscle cells (VSMCs) of the adult cardiovascular system suggest that these transcriptional regulators are critical for maintaining region-specific physiological properties of blood vessels.
Parnell, Schlichter et al. found that the RSC complex helps to activate genes by establishing or maintaining regions of nucleosome-poor chromatin at a promoter.
JONDI generates blocky artifacts; however, it maintains regions of high texture (box C).
The detected redundant regions were smaller than 3.0 Mb (range: 0.1-3.0 Mb), indicating the scale of the maintained regions after hexapolyploidization.
Our study differs in that we attempt to identify gene pairs (gene families with only two members) created by duplication early in mammalian radiation that have maintained regions of high sequence similarity due to ongoing gene conversion.
Montane cloud forests are crucial to maintaining the region's water balance, preventing landslides and massive floods.
New Jersey and authority staff disagree and say that the lease arrangement and its attendant dredging and channel-widening is crucial to maintaining the region's competitiveness and thousands of jobs in New Jersey and New York.
We can conclude that in normal cells PARylated Parp1 (or a PARylated transcription factor) occupies the Dnmt1 promoter, maintaining this region unmethylated.
We can, at least, consider that upwelling hydrothermal fluids, supplied from a deeper part, are maintained in region R1, covered by the low-permeability cap C1.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com