Sentence examples for maintaining protein quality from inspiring English sources

Until this study, the beneficial role of OMI in the mitochondrion has largely been considered as one of maintaining protein quality and turn over.

Recent studies into the insulin gene (INS) discovered a polymorphism in a 5' non-coding intron that influences the likelihood of intron retention in the final mRNA, extending the 5' untranslated region and maintaining protein quality.

Degradation via the UPS has roles in maintaining protein quality control, signaling, and cell cycle progression [ 1, 2].

Understanding how energy-dependent proteases and chaperones function to maintain protein quality control is key to high-level synthesis of recombinant products.

These molecular chaperones coordinate key processes needed to maintain protein quality, especially under conditions of increased cellular stress.

The main function of Hsp90 complexes is to maintain protein quality control and assist in protein degradation via proteasomal and autophagic-lysosomal pathways [ 98].

The E3 ligase C terminus of Hsc-70 interacting protein (CHIP) has a protective role against various stresses by targeting damaged proteins for proteasomal degradation, and thus maintains protein quality control.

Overall, the data suggest that deletion of MuRF1 maintains protein quality control in skeletal muscle, leading to reductions in endoplasmic reticulum and oxidative stress and the maintenance of muscle mass and growth capacity.

Unlike in disease, normally HSPs maintain protein quality control by several mechanisms including folding nascent protein, refolding and reactivation of unfolded and misfolded proteins, assembly and disassembly of macromolecular protein structures, and targeting abnormal and inactive proteins for degradation [ 5, 26, 27].

The liver is extremely metabolically active, and autophagy is important in recycling cellular nutrients, maintaining protein folding quality control and also in maintaining mitochondrial health, which is vital for energy homeostasis [ 25, 39].

A growing body of evidence suggests that basal autophagy has a relevant homeostatic role in maintaining protein and organelle quality control, acting in parallel with the UPS to prevent accumulation of poly-ubiquitinated and aggregated proteins.