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This can be achieved using site-specific labelling methods that exert maximum control over the number and site of modification(s) to the molecule, while still maintaining protein function.
This stands in contrast to other protein engineering techniques, like random point mutagenesis, in which the probability of maintaining protein function declines exponentially with increasing amino acid substitutions.
Protein surfaces rich in acidic residues probably play an essential role in maintaining protein function under alkaline conditions.
In their analysis, the authors predicted the impact of each variant on maintaining protein function using the predicting algorithm PolyPhen [19].
A majority of the Pgi coding sequence is conserved by strong purifying selection maintaining protein function.
These mechanisms are ruled by two evolutionary pressures: maintaining protein function and varying the antigens present within the proteins.
Similar(52)
Consequently, cells able to maintain protein function in the alternating anaerobic:aerobic sludge cycling are favoured.
Stress responses classically involve heat shock proteins or molecular chaperones that maintain protein function or repair damage after cell injury.
All the four ω ratios are much lower than one (ω<0.2), indicating that MEF2A-D proteins are subject to strong purifying selection to maintain protein function.
These findings indicate that the NS5A protein is undergoing purifying selection, which maintains protein function and therefore virus activity.
Under this model, the estimate of ω was 0.19, indicating that NAT1 sequences have been subject to strong purifying selection to maintain protein function over time.
More suggestions(15)
maintaining protein bioactivity
maintaining lung function
maintaining protein expression
maintaining protein kinase
maintaining protein conformation
maintaining protein quality
maintaining brain function
maintaining protein homeostasis
maintaining muscle function
maintaining protein stability
maintaining photoreceptor function
maintaining protein structure
maintaining barrier function
maintaining protein architecture
maintaining protein synthesis
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