Sentence examples for maintaining pluripotency of from inspiring English sources

Our limited basic knowledge on the requirements for maintaining pluripotency of adult pluripotent stem cells and the lack of appropriate markers associated with pluripotency hinders the progress toward their wide spread application.

All the results from ESCs and iPSCs indicate that both Tet1 and Tet2 are associated with maintaining pluripotency of early embryonic cells.

Our results suggest that Mbd3 is involved in maintaining pluripotency of mouse ES cells by repressing trophectoderm differentiation.

To better understand the functions of the NuRD complex in maintaining pluripotency of mouse ES cells, we investigated its functional components.

The final set of studies were directed at validating the expression of two different candidate genes Nanog and Methyl-CpG binding domain protein 2. The data related to Nanog is first presented since it has been shown to be a central component in maintaining pluripotency of ESC and is related to repression of ESC response to BMP signaling [53].

These genes are essential for maintaining pluripotency of embryonic stem (ES) cells and early embryos [8], [9], [10] and are also known as two of four genes which have been shown to reprogram somatic cells to pluripotent stem (iPS) cells with the essential characteristics of embryonic stem (ES) cells [11].

EGF and FGF2 have been reported to be necessary to maintain pluripotency of hES cells [22].

Cells were immunoreactive to the pluripotency markers, demonstrating the ability to maintain pluripotency of the investigated stem cells on chip.

Together, Oct4, Nanog, Sox2 and Sall4 form a regulatory circuit to maintain pluripotency of ESCs, prompting our exploration of these factors [36] [38].

One key prediction of the resulting dynamics is that over-expression of Nanog can maintain pluripotency of the cell even in the absence of the external factor(s) inducing Oct4 and Sox2.

Moreover, it has been proposed that dynamic placement of cohesin complexes by pluripotency transcription factors, contributes to a chromosome organization that maintains pluripotency of embryonic stem cells.