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EC lining the lumen of all blood vessels play essential roles in maintaining normal vascular function and in vascular homeostasis [1].
It is clear that NTs play an important role in maintaining normal vascular tone, oxidative homeostasis and in the regulation of the response of both endothelial and vascular smooth muscle cells to injury [35], [37].
These mice develop hypertension in part via functional changes to VSMC and this indicates an essential role of Rap1 (and possibly Epac) in maintaining normal vascular physiology.
cAMP is a central signaling molecule in a variety of cellular systems and plays an important role in maintaining normal vascular function.
It has become increasingly clear that pericytes are vital in maintaining normal vascular homeostasis and regulating vascular phenotype in disease [ 3].
In the adult brain, Notch3 is expressed in the vascular smooth muscle cells of small vessels and it is essential for maintaining normal vascular structure and function (Ayata, 2010; Joutel et al., 2010).
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Furthermore, dexamethasone reduces vascular permeability and maintains normal vascular responsiveness to circulating vasoconstrictor factors.
Cardiovascular effects occur to maintain normal vascular reactivity during the stress period.
ECE-1 localizes to the small secretory vesicles of the constitutive pathway from where ET-1 is continuously released to maintain normal vascular tone.
The dynamic equilibrium of ET-1 and NO is important to maintain normal vascular angiotasis and hemodynamics, and such a balance can regulate endothelial cell proliferation and platelet aggregation [ 7, 8].
Furthermore, RPE secretes several factors, which are involved in maintaining normal retinal vascular homeostasis such as platelet-derived growth factor (PDGF) [ 13], pigment epithelium-derived factor (PEDF) [ 14], and vascular endothelial growth factor (VEGF) [ 15– 17].
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maintaining normal cytoskeletal
maintaining normal visual
maintaining normal social
maintaining normal physical
maintaining normal immune
maintaining normal mitochondrial
maintaining normal endothelial
maintaining normal cardiac
maintaining normal cerebral
maintaining basal vascular
maintaining normal cellular
maintaining normal blood
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