Because of this protein's vital role in maintaining normal cellular function, tumor cells have developed numerous methods to disable its function.
In cancer radiotherapy, knowledge of normal tissue responses and toxicity risks is essential in order to deliver the highest possible absorbed dose to the tumor while maintaining normal tissue exposure at non-critical levels.
The metabolic functions of p53 are emerging as critical not only for tumor suppression but also for maintaining normal cellular homeostasis.
These metabolic functions of p53 are emerging as important components of the p53 response that not only aid in maintaining normal cellular homeostasis but also contribute to the control of tumor development.
These literatures regarding CXCR4 indicate that CXCR4 signaling is not limited to promote tumor progression only; it is also involved in maintaining normal homeostasis of cells/tissue.
Taken together, we discovered that INPP4B is a novel suppressor of oncogenic PKC signaling, further emphasizing the role of INPP4B in maintaining normal physiology of the prostate epithelium and suppressing metastatic potential of prostate tumors.
Recently, miRNAs have been demonstrated to play important roles in maintaining normal cellular functions, and the dysregulation of miRNAs could lead to the initiation and progression of tumors [ 15, 16].
The tumor suppressor gene PTEN (phosphatase and tensin homolog on chromosome ten) plays a critical role in maintaining normal cell activities.
Moreover, suitable tumor vasculature is also important for removing the metabolic waste produced by tumors, to maintain normal metabolic processes and for tumor development [ 3].
Cadherin 1 (CDH1), which encodes a transmembrane glycoprotein, is a classic TSG at 16q22.1 and acts as a key cell-cell adhesion molecule to maintain normal tissue architecture and inhibit tumor initiation [25].
