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Irs2 expression is significantly reduced in pancreatic islets from humans with Type 2 diabetes (Gunton et al. 2005), consistent with a critical role for IRS2 in maintaining normal sensitivity to insulin.
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This is not the case for HOZOT because HOZOT maintains normal sensitivity to IL-2 even with low expression of miR-155.
At physiologic levels, E2 is thought to be involved in maintaining normal insulin sensitivity and to be beneficial for β-cell function (Livingstone and Collison 2002; Louet et al. 2004).
Although physiological levels of E2 are involved in maintaining normal insulin sensitivity (Liu and Mauvais-Jarvis 2010; Louet et al. 2004), E2 outside of the physiological range may have adverse effects on glucose homeostasis (Livingstone and Collison 2002; Nadal et al. 2009a).
Accumulating evidence suggests that ERα plays a pivotal role in maintaining normal body weight and insulin sensitivity, whereas ERβ seems to have the opposite effect (32, 33).
Through 4 weeks of HF feeding, KO mice, unlike WT mice, maintained normal insulin sensitivity.
Most of the studies that address this issue have focused on the physiological concentration of testosterone, which maintains normal insulin sensitivity but has deleterious effects on the same when the concentration of testosterone is out of this range.
Adult female offspring of High or Low LG mothers were ovariectomized and implanted bilaterally with estrogen capsules (40 mm, 1 mg/ml E2B) that mimic the low circulating levels of estradiol typical of diestrus and maintain normal estrogen sensitivity [37], [38].
Maintaining normal social contact is important to well-being.
Protein homeostasis is crucial for maintaining normal cellular function.
Maintaining normal cell morphology may also be essential for differentiation.
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