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OPA1 promotes mitochondrial fusion and is essential for maintaining normal mitochondrial morphology.
Thus, mitochondrial protein import is essential for maintaining normal mitochondrial function.
This result suggests that mtDNA is required for maintaining normal mitochondrial structures in S. pombe.
Here we show that iPLA2-VIA, the Drosophila homologue of PLA2G6, plays an essential role in maintaining normal mitochondrial function.
In skeletal muscle tissue, maintaining normal mitochondrial morphology and function is essential for keeping of normal skeletal muscular function.
These results underscore the necessity for maintaining normal mitochondrial dynamics and function in order for Myc to regulate several of its fundamental phenotypes.
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This dynamic network is essential to maintain normal mitochondrial functions and participates in fundamental processes including aging.
Unfortunately, targeting of BCL-2 also causes adverse effects, presumably because many normal cells depend on proteins in the BCL-2 family to maintain normal mitochondrial function.
Moreover, it has been reported that mitochondrial dynamics, a continuous mitochondrial fusion and fission, is necessary to maintain normal mitochondrial respiratory function in mammals (Chen et al. 2010; Ishihara et al. 2009).
These factors are interdependent for example, cardiolipin is required for both respiratory supercomplex assembly and Mgm1/OPA1 self-assembly and function and the prohibitins are required to maintain normal mitochondrial lipid homeostasis (DeVay et al., 2009; Osman et al., 2009).
Interestingly, STAT3 independently from its transcriptional function is necessary to maintain normal mitochondrial bioenergetic function, which is dependent on Ser-727 whose phosphorylated form is highly enriched in mitochondria [ 95, 96]; reviewed in [ 97].
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maintaining northern mitochondrial
maintaining normal cytoskeletal
maintaining normal social
maintaining adequate mitochondrial
maintaining peroxisomal mitochondrial
maintaining optimal mitochondrial
maintaining normal cardiac
maintaining normal cellular
maintaining normal glycaemic
maintaining normal whole-plant
maintaining normal respiratory
maintaining normal vascular
maintaining normal physiological
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