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These results suggest that Bcl-2 may be important in maintaining normal breast function.
Cell-cell adhesion molecules (including E-cadherins and tight junction proteins such as ZO-1 (zona occludens 1)) play a pivotal role in maintaining normal breast epithelial architecture.
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The increased R2* in normal breast tissue has also been related to the fibrocollagenous ligaments of Cooper, which maintain normal breast structural integrity and contribute to higher R2* values.
Proper coordination of all of these activities is necessary to maintain normal breast function; accordingly, it is unsurprising that the loss of myoepithelial function is almost universally associated with breast cancer [ 1, 15, 17].
The encoded protein is involved in repairing cell damage and maintaining normal growth of breast cells [ 29].
We suggest that it serves at least a two-fold purpose: (1) to activate the proliferative MAP/ERK kinase pathway and (2) to block STAT 5-mediated responses to trophic hormones, which maintain normal differentiated breast cell phenotype as exemplified by the lack of mammary gland development in CIS transgenic mice (Matsumoto et al, 1999).
Essential role of DOT1L in maintaining normal adult hematopoiesis.
Restoring and maintaining normal rhythm is no small feat.
The cancer cell has to overcome many levels of regulation that maintain normal cellular growth for breast cancer to evolve to this advanced state.
The present study showed that representative molecules contributing to establishment of cell polarity (junctional structures, domain identity and Rho family members), as well as MUC1 were well maintained in normal breast tissue, but disrupted by various degrees in human breast cancer subtypes.
Donor must maintain normal weight.
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