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These genes are part of signaling pathways important for maintaining neuronal function in the nigrostriatal pathway.
Within the group of genes showing differential expression, the sialyltransferases (SiaTs) and GalNAc-Ts that were elevated at P7 prefer glycoprotein substrates, whilst the SiaTs and GalNAc-Ts that were elevated in the adult preferentially modify glycolipids, consistent with a role for gangliosides in maintaining neuronal function in the adult.
Several studies have demonstrated the role of RSV in maintaining neuronal function in rodents (see [18] for review).
Our results suggest that, while neurons may have variable amounts of ion channel mRNA, correlations exist between channel transcripts that may aid in maintaining neuronal function.
The autosomal recessive models have uncovered the importance of mitochondrial QC and transport for maintaining neuronal function and integrity.
The protein product of this gene catalyzes the breakdown of neurotoxic quinolinate in the tryptophan nicotinamide adenine dinucleotide pathway, preventing the intracellular accumula tion of toxic compounds and maintaining neuronal function.
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It is plausible that Dnmt1 activity complements other DNA methyltransferases to maintain neuronal function.
Reactive gliosis may have beneficial and detrimental effects and is considered as an attempt to maintain neuronal function, protecting the tissue from further destruction, and to initiate tissue regeneration.
Microtubule-associated protein tau encoded by the MAPT gene binds to microtubules and is important for maintaining neuronal morphology and function.
In addition to neurons, ischaemia also causes damage to astrocytes (Martin et al., 1997; Yu et al., 2001; Lukaszevicz et al., 2002; Giffard and Swanson, 2005), which are critical in maintaining neuronal viability and functions under ischaemic conditions.
These observations suggest that MUL1 acts in parallel to the PINK1/parkin pathway to ensure mitochondrial integrity and function, thus maintaining neuronal health in primary cortical neurons.
More suggestions(15)
maintaining musculoskeletal function
maintaining neuronal integrity
maintaining neuronal plasticity
maintaining neuronal polarity
maintaining neuronal morphology
maintaining neuronal gene
maintaining hematopoietic function
maintaining ecological function
maintaining normal function
maintaining endothelial function
maintaining neuronal maturation
maintaining neuronal differentiation
maintaining synaptic function
maintaining visual function
maintaining neuronal shape
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