Tamai et al. reported that LETM1 has a distinct role in mitochondrial biogenesis by maintaining mitochondrial volume and shape that helps achieve efficient assembly of respiratory chains [ 9].
Mitochondrial dynamics refers to the processes maintaining mitochondrial homeostasis, including mitochondrial fission, fusion, transport, biogenesis, and mitophagy.
In other terms, the failure of maintaining mitochondrial function through biogenesis may contribute to bad outcome.
Cardiolipin (CL) has a critical role in maintaining mitochondrial inner membrane structure.
In eukaryotes, mitochondrial fusion-fission is important for maintaining mitochondrial numbers and morphology, and plays a critical role in sustaining functional mitochondria [32,33].
Mammalian mitochondria have their own NAD biosynthetic machinery which plays a key role in maintaining mitochondrial NAD pool [13, 115].
In the case of Parkinson's disease, many signposts point to disruption of mitochondrial health as a major factor and thus the importance of mitochondrial transport in maintaining mitochondrial health takes on great relevance.
This report highlights a novel function of PINK1 in mitochondrial biogenesis and a role in maintaining mitochondrial ETC activity.
Controlling mitochondrial remodeling process is not only important for maintaining mitochondrial morphology but also for mitochondrial functions, which may determine the cellular activity and survival [17].
Mitochondrial network dynamics, particularly, mitochondrial fission and fusion, participate in maintaining mitochondrial function.
