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While no consensus has been reached, it appears likely that both Omi and Parkin act via parallel pathways, with respect to Pink-1, in maintaining mitochondrial integrity.
All of this has led to a multi-factorial mechanism for maintaining mitochondrial integrity, where the role of OMI was downstream of Pink-1 (which in turn was upstream of Parkin), but was independent of Parkin [29], [31], [32].
Anti-apoptotic Bcl-2 proteins sequester pro-apoptotic Bcl-2 proteins, thus maintaining mitochondrial integrity.
Reviewer 3: MUL1 compensates for loss of PINK1/parkin in maintaining mitochondrial integrity.
Hence, by maintaining mitochondrial integrity, basal p53 activity may also limit ROS production.
To examine whether Crif1 is a key molecule for maintaining mitochondrial integrity, either scrambled or Crif1 cDNA was transfected into SH-SY5Y cells.
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Multiple studies revealed that H2S donors help maintain mitochondrial integrity, reduce the release of mitochondrial death signals, and attenuate mitochondrially-regulated cell death responses of various types 79, 81, 82.
Our studies demonstrate that Grx1, a cytosolic oxido-reductase, helps maintain mitochondrial integrity and prevents MMP loss caused by oxidative insult.
TEM analysis of young and aged human neurons lacking PINK1 also revealed an increase in the proportion of abnormal swollen mitochondria within cells (Figure 5F,G) further supporting the hypothesis that PINK1 functions to maintain mitochondrial integrity in neurons.
All steps were performed at 4°C to maintain mitochondrial integrity.
All procedures were performed at 4 °C to maintain mitochondrial integrity.
More suggestions(15)
maintaining mitochondrial distribution
maintaining mitochondrial function
maintaining mitochondrial shape
maintaining chromosomal integrity
maintaining mitochondrial stability
maintaining mitochondrial performance
maintaining centromere integrity
maintaining structural integrity
maintaining genome integrity
maintaining vascular integrity
maintaining mitochondrial morphology
maintaining cellular integrity
maintaining academic integrity
maintaining mitochondrial ΔΨm
maintaining mitochondrial quality
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