Mitochondria are highly dynamic that undergo continuous fission and fusion processes, which are important for maintaining mitochondrial morphology, distribution, and functions.
Among the major mammalian fission proteins, dynamin-related protein 1 (Drp1) has additional roles in maintaining mitochondrial shape, size, distribution and cristae remodeling.
Mitochondrial dynamics refers to the processes maintaining mitochondrial homeostasis, including mitochondrial fission, fusion, transport, biogenesis, and mitophagy.
In other terms, the failure of maintaining mitochondrial function through biogenesis may contribute to bad outcome.
In eukaryotes, mitochondrial fusion-fission is important for maintaining mitochondrial numbers and morphology, and plays a critical role in sustaining functional mitochondria [32,33].
Cardiolipin (CL) has a critical role in maintaining mitochondrial inner membrane structure.
Mammalian mitochondria have their own NAD biosynthetic machinery which plays a key role in maintaining mitochondrial NAD pool [13, 115].
In the case of Parkinson's disease, many signposts point to disruption of mitochondrial health as a major factor and thus the importance of mitochondrial transport in maintaining mitochondrial health takes on great relevance.
The ER mitochondria organizing network (ERMIONE) in Saccharomyces cerevisiae is involved in maintaining mitochondrial morphology and lipid homeostasis.
This report highlights a novel function of PINK1 in mitochondrial biogenesis and a role in maintaining mitochondrial ETC activity.
