Sentence examples for maintaining high receptor from inspiring English sources

These observed SAR suggest that, within this class of compounds, the number of HB-donor groups can be lowered while maintaining high receptor affinity.

Our results indicate that the NMeGly for Gly substitution and the Sta-Leu substitution at the C-terminus confer high serum stability while maintaining high receptor affinity, resulting in biodistribution properties that outperform those of the other peptides.

APY-βAla8.am binds to EphA4 with nanomolar affinity while maintaining high receptor specificity.

This mechanism allows growth factor receptors such as EGFR, IGFR, and HER-2 to be expressed and properly folded, maintaining high levels of these receptors in tumor cells.

This initial SAR suggests pharmacophoric elements that may be modified to modulate/increase opioid affinity, while maintaining high affinity for the NOP receptor, to result in potent bifunctional small-molecule NOP/MOP ligands.

The majority of the synthesized compounds maintained high affinity for 5-HT7 receptors and showed selectivity towards 5-HT6 andopaminene D2 receptors and different selectivity for 5-HT1A and α1 adrenergic receptors.

The addition of the smaller dansyl fluorophore to XAC resulted in a molecule that maintained high affinity at the A1 receptor, comparable with that of the parent XAC molecule.

In this manner, in contrast to peptides and other large ligands, GPCR ligands are often small molecules, and their fluorescent derivatives, if properly functionalized, can maintain high affinities for their cognate receptors.

Our experiments on cells engaged by anti-HER2 Abs showed that fast receptor internalization and degradation was followed by rapid reexpression of new HER2 molecules on the membrane surface, consistent with the capability of these cancer cells to restore and maintain high expression levels of the amplified HER2 receptor.

In complexes of compound 5 with receptors, the angle between both rings maintains high values (57.4° for 5-HT1A and 67.3° for 5-HT7, respectively).

Ruvkun and his colleagues suggest that during times of plenty, the worm maintains high levels of an insulin-like hormone, which binds to the DAF-2 receptor.