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Hence, IL-3R is a potential therapeutic target for maintaining hematopoietic function following irradiation.
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A number of these genes have an already identified role in maintaining hematopoietic stem cells directly (EVI1) or indirectly (ENST00000353442) by altering the expression of genes implicated in the maintenance of stem cell function such as sonic hedgehog [38].
Other work suggests that FoxO3a alone may play a role in maintaining hematopoietic stem cells, since hematopoietic stem cells are decreased in aged FoxO3 −/− mice compared to the littermate controls [ 222].
In conclusion, PTH acts with Flt-3L to maintain hematopoietic cells by limiting apoptosis.
Mesenchymal stromal cells and osteoblast progenitors are maintained into niches of the bone marrow [20], where they also contribute to maintain hematopoietic stem cells [34].
Equilibrium signaling maintains hematopoietic progenitors in the developing lymph gland.
Namely, PTH acts with Flt-3L to maintain hematopoietic cells by limiting apoptosis.
Deletion of Foxo1, Foxo3a, and Foxo4 or a single deletion of Foxo3a also blocks the repopulation of hematopoietic stem cells in murine models [ 186, 222], illustrating the need for FoxO proteins to maintain hematopoietic stem cells.
All patients demonstrated recovery of hematopoietic function.
As these functional annotations are attributes of hematopoietic cells, these results compellingly suggest that splicing diversity is involved in the molecular mechanisms that mediate hematopoietic function and differentiation.
In the majority of cases, liver, renal, and hematopoietic function normalizes after 5 days.
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