Methylation levels of long interspersed nucleotide elements (LINE-1) are representative of genome-wide methylation status and play an important role in maintaining genomic stability and gene expression.
Ashton, N. W. et al. Human single-stranded DNA binding proteins are essential for maintaining genomic stability.
These data therefore implicate PTEN in maintaining genomic stability by allowing time for DNA repair by HR before cells enter mitosis.
Collectively, these data implicate PTEN in maintaining genomic stability by delaying G2/M-phase progression of damaged cells, thus allowing time for DSB repair by HR.
Studies in the laboratory are beginning to unravel the complex set of molecular events that are critical for maintaining genomic stability following DNA damage.
Emerging evidence shows that Uhrf1 plays an important role in DNA damage response for maintaining genomic stability.
Our results demonstrate that the interaction between NORAD and RBMX is important for NORAD function, and that NORAD is required for the assembly of the previously unknown topoisomerase complex NARC1, which contributes to maintaining genomic stability.
On the other hand, controlled generation of ROS is involved in cellular signaling29 and has an important role in maintaining genomic stability in stem cells30 as well as in neuronal development and differentiation31.
DNA repair genes are important for maintaining genomic stability and limiting carcinogenesis.
Mismatch repair is essential for maintaining genomic stability of all organisms.
The DNA damage response (DDR) and DNA repair are critical for maintaining genomic stability and evading many human diseases.
