Thus, SIRT1 plays a protective role in maintaining genomic integrity not only against genotoxic stress but also to attenuate neurodegeneration.
As one of the DNA damage repair enzymes, uracil-DNA glycosylase (UDG) plays an important role in maintaining genomic integrity.
Chk2 (checkpoint kinase 2) is a serine/threonine kinase that participates in a series of signaling networks responsible for maintaining genomic integrity and responding to DNA damage.
Therefore, our study suggested that Gadd45a has a unique role in preventing the exhaustion of the self-renewal capacity in ATM deficient HSCs, probably through promoting DNA repair and maintaining genomic integrity in ATM−/− HSCs.
Homologous recombination is essential for maintaining genomic integrity.
For example, SUMOylation is known to play an important role in maintaining genomic integrity and preventing tumorigenesis.
Recent studies have implicated that Sirt1 may play a role in maintaining genomic integrity [16], [28] in mammalian cells.
Once the information encoded in DNA is lost, it cannot be replaced, therefore these pathways are vital for maintaining genomic integrity and preventing carcinogenesis [1].
Maintaining genomic integrity is vital for the stem cell because mutations will severely compromise all derived cell lineages and their progenies.
Similarly, several DNA repair genes (Lig1, Poln, Gtf2h5) also lose the H3K4/K27me3 double mark of the ICM to retain H3K4me3 in ESCs, suggesting an involvement of these genes in maintaining genomic integrity in rapidly dividing cells.
Our results indicate that Cav-1 may play a critical role in sensing genotoxic stress and in orchestrating the response of cells to DNA damage through regulating the important molecules involved in maintaining genomic integrity.
