maintaining genome integrity

USAGE SUMMARY

The phrase "maintaining genome integrity" is correct and usable in written English.
It can be used in scientific or academic contexts, particularly in discussions related to genetics, molecular biology, or biotechnology. Example: "Researchers are focused on understanding the mechanisms involved in maintaining genome integrity to prevent mutations that could lead to diseases."

✓ Grammatically correct

Science

Human-verified examples from authoritative sources

Exact Expressions

60 human-written examples

Functional telomeres are essential for maintaining genome integrity; telomere shortening resulting from telomere dysfunction leads to genomic instability, which is a common cause and hallmark of cancer [ 29- 31].

Aging

Nishi, R. et al. Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity.

Nature

Here we focus on recent insights into the functions of telomere positioning in maintaining genome integrity.

Current Opinion in Cell Biology

Maintaining genome integrity is crucial for successful organismal propagation and for cell and tissue homeostasis.

Current Opinion in Cell Biology

Despite its central role in maintaining genome integrity, little is known about its overall architecture.

Cell Reports

Maintaining genome integrity and transmission of intact genomes is critical for cellular, organismal, and species survival.

Cell Host & Microbe

Beck, H. et al. Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase.

Nature

Maintaining genome integrity in germ cells is important, given that the germ cells produce the next generation of offspring.

DNA Repair

Members of the RecQ family play critical roles in maintaining genome integrity.

Duke University

Due to its role in maintaining genome integrity, HR is often considered the dernier resort in preventing tumorigenesis [70].

Clinical and Translational Medicine

All of these DNA polymerases and primases require a Fe-S cluster for the formation of active holoproteins, implying the importance of iron in maintaining genome integrity (Netz et al., 2012).

Protein & Cell

Expert writing Tips

Best practice

When discussing cancer or inherited diseases, use "maintaining genome integrity" to underscore the importance of preventing mutations and chromosomal abnormalities. For example, mention how certain proteins are essential in "maintaining genome integrity" and preventing the development of tumors.

Common error

Avoid exaggerating the impact of minor genetic variations by claiming they automatically compromise "maintaining genome integrity". Instead, specify the exact mechanisms and potential consequences when discussing genetic changes.

Linguistic Context

The phrase "maintaining genome integrity" functions as a noun phrase often serving as the object of a verb or the subject complement. It describes the ongoing process of preserving the complete and correct genetic information within an organism's cells. Ludwig provides numerous examples showcasing this usage.

Expression frequency: Very common

Frequent in

Science

100%

Less common in

News & Media

0%

Formal & Business

0%

Academia

0%

Ludwig's WRAP-UP

In summary, "maintaining genome integrity" is a crucial process for preserving the complete and accurate genetic information within cells. Ludwig AI confirms that the phrase is grammatically correct and predominantly used in scientific contexts. It describes the importance of cellular mechanisms preventing DNA damage and mutations. Related phrases include "preserving genomic stability" and "safeguarding genetic integrity". When using this phrase, it's best to highlight the concrete mechanisms and potential consequences. The frequency of use is very common in scientific literature, emphasizing its significance in discussions related to genetics, molecular biology, and cancer research.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

preserving genomic stability

Focuses on the aspect of stability rather than the process of maintaining.

safeguarding genetic integrity

Emphasizes the protection aspect, implying a proactive approach to prevent damage.

ensuring genomic robustness

Highlights the ability of the genome to withstand disturbances and maintain functionality.

protecting genetic information

Shifts the focus to the preservation of the information encoded in the genome.

upholding genomic correctness

Stresses the importance of accuracy and fidelity in the genome's structure and sequence.

conserving genome sequence

Highlights the importance of preserving the original order of nucleotides in DNA and preventing mutations.

assuring genetic fidelity

Emphasizes the accuracy in replication and transmission of genetic material.

sustaining chromosome integrity

Narrows the focus to the physical structure of chromosomes and their preservation.

securing DNA integrity

Implies an active role in protecting DNA structure.

promoting genetic stability

Indicates an approach to encourage stable genetic processes.

FAQs

How is "maintaining genome integrity" essential for cells?

"Maintaining genome integrity" is vital for cells because it ensures accurate replication, prevents mutations, and safeguards against genomic instability, all of which are crucial for cellular survival and proper function. Without effective mechanisms for "preserving genomic stability", cells can accumulate harmful genetic alterations that lead to diseases like cancer.

What factors affect the process of "maintaining genome integrity"?

Various factors can impact "maintaining genome integrity", including exposure to radiation, oxidative stress, errors during DNA replication, and defects in DNA repair pathways. Additionally, certain genetic mutations can compromise a cell's ability to effectively repair damaged DNA, further affecting "safeguarding genetic integrity".

Which cellular mechanisms are involved in "maintaining genome integrity"?

Several cellular mechanisms are involved in "maintaining genome integrity", such as DNA repair pathways (e.g., base excision repair, mismatch repair, homologous recombination), cell cycle checkpoints, and telomere maintenance. These processes work together to detect and repair DNA damage, prevent the propagation of mutations, and ensure proper chromosome segregation, thus "protecting genetic information".

Can lifestyle choices influence "maintaining genome integrity"?

Yes, lifestyle choices can significantly influence "maintaining genome integrity". For example, a diet rich in antioxidants, regular exercise, avoiding smoking and excessive alcohol consumption, and limiting exposure to environmental toxins can all help reduce DNA damage and support effective DNA repair mechanisms. Conversely, unhealthy habits can increase the risk of DNA damage, thereby compromising "ensuring genomic robustness".