It serves as an adherent molecule to maintain epithelial phenotype of cell thereby inhibiting cell invasiveness.
Ephrin-A1 (EFNA1) ligand binding to the EphA2 receptor at sites of cell-cell contact maintains epithelial phenotype and integrity in part by downregulating Akt, Rho/Rac and Ras pathway signaling [ 82- 84].
Similar to endothelial cells, epithelial cells' AJs contribute to maintaining epithelial barrier integrity (Mezzano et al., 2014).
E-cadherin (epithelial cadherin) is essential for maintaining epithelial integrity of many embryonic and adult tissues.
However a dramatic inhibition of cardiac EMT resulting in the majority of cells maintaining an epithelial phenotype (rounded and non-invasive) was observed with WNT16 sequestration (Fig. 4B; gel surface image).
MCDB105 (a modification of medium F12) was found to enhance the growth potential of normal OSE while maintaining the epithelial phenotype.
During kidney development, BMP-7 plays an important role in promoting mesenchymal-to-epithelial transition (MET) and maintaining TEC epithelial phenotype [ 32] whereas TGF- β is a major cytokine that regulates EMT.
The miR-200 family inhibits the initiating step of metastasis, the epithelial mesenchymal transition (EMT), by maintaining the epithelial phenotype through directly targeting the transcriptional repressors of E-cadherin, ZEB1 and ZEB2.
3, 4 Recent studies have shown that BMP7 maintains epithelial and endothelial phenotypes against epithelial-mesenchymal transition (EMT).
Furthermore, the bioactive membranes helped to support and maintain renal epithelial phenotype and function.
