The hypothesis of stromal cells involvement in tumorigenesis is based on a study of embryological development where interactions between various cells are necessary for programming and maintaining epithelial structure and function.
A role for stromal cells in carcinogenesis has been suggested from studies of embryological development where instructive and permissive interactions, along with genetic factors, are required for programming and maintaining epithelial structure and function.
Similar to endothelial cells, epithelial cells' AJs contribute to maintaining epithelial barrier integrity (Mezzano et al., 2014).
Regulation of cholangiocyte survival is crucial for maintaining epithelial cell integrity in the biliary tract.
E-cadherin (epithelial cadherin) is essential for maintaining epithelial integrity of many embryonic and adult tissues.
HNT expression is also essential for maintaining epithelial integrity for amnioserosa, and retinal epithelium.
This further suggests that the BMP pathway is important in maintaining epithelial cell homeostasis.
E-cadherin is a calcium-dependent transmembrane glycoprotein involved in maintaining epithelial adherent junctions.
E-cadherin/β-catenin protein complexes are essential for maintaining epithelial integrity.
http://dx.doi.org/10.1016/j.ceb.2013.06.010 Building and maintaining epithelial tissues is a complex process.
