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Exact(7)
Regulation of cholangiocyte survival is crucial for maintaining epithelial cell integrity in the biliary tract.
This further suggests that the BMP pathway is important in maintaining epithelial cell homeostasis.
This suggests that normally Dlc1 plays a role in maintaining epithelial cell polarity and that it is haploinsufficient.
We investigated in silico the expression of 369 genes experimentally recognized as involved in establishing and maintaining epithelial cell identity and mammary gland remodeling, in HELUs or ADHs with respect to the corresponding patient-matched normal tissue.
In particular, gene expression profiling and ChIP-seq studies enabled us to demonstrate that Ezh2 plays a novel role in maintaining epithelial cell lineage specification by depositing H3K27me3 repressive marks at the promoters of basal genes in the epithelium.
Villus epithelial cells also displayed clear increases in the expression of several growth and differentiation associated genes, and genes involved in establishing and maintaining epithelial cell polarity, as compared to the levels observed in crypt epithelial cells.
Similar(53)
Of the sixty two, cell differentiation genes identified in LEC only five were upregulated (table 2) these were involved in maintaining epithelial cells in an undifferentiated state.
Particularly, the members of miR-200 family maintain epithelial cell integrity by suppression of EMT via direct inhibition of mesenchymal transcription factors zinc finger E-box-binding homeobox 1/2 (ZEB1/ZEB2) and TGF-β, a potent inducer of EMT.
This apical targeting of AJs also helps to establish and maintain epithelial cell polarity.
In contrast with normal physiological stroma, which maintains epithelial cell polarity and inhibits epithelial cell growth and transformation, tumour stroma may stimulate the whole tumour development process [ 1].
Although some epithelia, such as the epidermis, almost completely die, others, such as the tracheal system, partially survive and their cells form vesicles that maintain epithelial cell polarity.
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maintaining epithelial turn
maintaining epithelial homeostasis
maintaining epithelial morphology
maintaining epithelial permeability
maintaining epithelial development
maintaining epithelial structure
maintaining epithelial polarity
maintaining epithelial integrity
maintaining epithelial architecture
maintaining epithelial adherent
maintaining normal cell
maintaining epithelial stem
maintaining high cell
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