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This study provides evidence that PPARα may have clinical applications toward maintaining endothelial function during ageing.
There is mounting evidence about the benefits of C. sinensis in maintaining endothelial function and vascular homeostasis and an associated reduction in atherogenesis and CVD risk.
It has become apparent that enzymatic "coupling" of endothelial NO synthase (eNOS) by the cofactor tetrahydrobiopterin (BH4) plays a key role in maintaining endothelial function.
This enzyme plays an important role in maintaining endothelial function [ 27], which is illustrated by the progressive renal failure observed in eNOS knock-out mice [ 28].
Emerging evidence supports a role for bone marrow-derived circulating endothelial progenitor cells in maintaining endothelial function and organ perfusion by mechanisms ranging from endothelial repair to postnatal angiogenesis and vasculogenesis [ 2].
Although the specific role of EPCs in maintaining endothelial function is unclear, it has been suggested that a reduction in EPC levels decreases normal turnover of endothelial cells thereby preventing endothelial repair and regeneration (Steinmetz et al. 2010).
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Second, smoking leads to endothelial dysfunction, and injured vessels may use PCs to maintain endothelial function [ 20].
This is a novel insight that corin plays a protective role and could maintain endothelial function in DCM.
The results suggest that NO-independent mechanisms can act as a salvage system to maintain endothelial function in situations associated with decreased NO bioavailability, at least in early periods of life.
In the vasculature, S1P plays an essential role in maintaining endothelial barrier function and regulating immune cell function [ 15, 21, 23].
Emerging evidence has suggested that APC might exert its clinical benefit, at least in part, by maintaining endothelial barrier function [ 3, 4].
More suggestions(15)
maintaining musculoskeletal function
maintaining endothelial tightness
maintaining endothelial homoeostasis
maintaining mitochondrial function
maintaining endothelial cell
maintaining endothelial access
maintaining normal function
maintaining ecological function
maintaining endothelial injury
maintaining executive function
maintaining everyday function
maintaining cardiac function
maintaining neuronal function
maintaining synaptic function
maintaining visual function
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