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One of the most important qualifiers in searching for better drug candidates for inhalation is to reduce systemic side effects while maintaining efficacy.
The use of prophylactic ofloxacin 200 mg given twice after BCG instillations appears to be a simple and practical method of improving BCG tolerability yet maintaining efficacy.
The goal of modern smaller field radiation therapy is to reduce both treatment volume and treatment dose while maintaining efficacy and minimizing acute and late sequelae.
Randomized comparisons should be restricted to studies designed to improve (eg, simplify or reduce costs) high cure rate therapies while maintaining efficacy.
A 6-mg dose of SC sumatriptan is the most efficacious and fast-acting acute treatment for migraine, but a 3-mg dose of SC sumatriptan may improve tolerability while maintaining efficacy.
Based on previous research [16], we hypothesized that a formulation using a lower doses of sumatriptan may improve safety and tolerability while maintaining efficacy similar to 6 mg SC sumatriptan, and that a 3-mg dose may be sufficient in many patients.
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Pesticide lasting validity period needs the sustained release of pesticides to maintain efficacy for a long time.
Research efforts aiming to optimize the delivery of WR-1065 to maintain efficacy while reducing its peak, systemic concentration below levels that induce hypotension are underway.
We hypothesized that controlled release of PHCCC from degradable nanoparticles (NPs) might address these challenges by altering DC function to maintain efficacy with reduced treatment frequency and toxicity.
Despite its success, this approach again requires multiple nasal administrations to maintain efficacy against EAE.
Proper placement and fixation of an ET tube is required to maintain efficacy of the airway.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com