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Maintaining dosing of imatinib in the face of isolated sites of disease progression is also important, as other metastatic sites may still be sensitive.
This patient also highlights the importance of maintaining dosing of imatinib mesylate in the face of isolated sites of disease progression, as other metastatic sites may still be sensitive.
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At week 24, Group 1 patients crossed over to golimumab 50 mg, Group 2 continued golimumab 50/100 mg per escape status and Group 3 maintained dosing.
To reduce the treatment time and ensure accurate dose delivery to moving targets, the number of intensity levels was minimized while maintaining dose coverage to PTV and minimizing dose to organs at risk (OARs).
To test whether reducing radiation dose to uninvolved bladder while maintaining dose to the tumor would reduce side effects without impairing local control in the treatment of muscle-invasive bladder cancer.
To reach steady-state levels of the antibody in question an initial dose of twice the maintaining dose was given 4 to 24 hours before wounding.
These results confirm the importance of tolerable treatment and maintaining dose intensity.
Improved dose individualization and avoidance of or reduction in the severity of toxicity would assist in maintaining dose intensity.
A recent review underscored the importance of maintaining dose levels sufficiently above coverage levels for serum A10-receptors [ 7].
This study further showed that low-dose intensities and treatment discontinuations were correlated with shorter survival times, indicating the importance of maintaining dose intensity.
Previous attempts to use thrombopoietin-stimulating agents have been successful at maintaining dose intensity, although antibody formation limited the use of these agents 24.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com