Your English writing platform
Discover LudwigExact(8)
Overall, we demonstrate heparin gel sandwich to be an excellent system for maintaining differentiated, polarized primary hepatocytes for over three weeks.
The sandwich culture of hepatocytes, between double layers of extra-cellular matrix (ECM), is a well-established in vitro model for re-establishing hepatic polarity and maintaining differentiated functions.
This cell line displays extended proliferative capacity while maintaining differentiated characteristics.
Homeobox (HOX) genes are transcription factors with roles in development, regulating patterning during embryogenesis and maintaining differentiated states.
Stem cells are responsible for maintaining differentiated cell numbers during normal physiology and at times of tissue stress.
Global miRNA expression is frequently reduced in tumor samples relative to normal tissues, suggesting a role for miRNA in maintaining differentiated cell phenotypes.
Similar(52)
Finally the use of surface modifications to maintain differentiated cells in their terminal phenotype is covered.
Ge, W. P., Zhou, W., Luo, Q., Jan, L. Y. & Jan, Y. N. Dividing glial cells maintain differentiated properties including complex morphology and functional synapses.
In conclusion, the findings described in this study make it possible to maintain differentiated primary mouse hepatocytes that also show GJIC in long-term culture for 30 days.
Pre-coating of Ln enhanced cell differentiation, as the maximum activity of a cell differentiation marker (alkaline phosphatase) was 2 3 times higher than on Fn-coated collagen, and maintained differentiated phenotype in long term (up to 21 days) culture.
Typically, this is achieved through the use of degradable biomaterials to either induce surrounding tissue and cell ingrowth or to serve as temporary scaffolds for transplanted cells to attach, grow, and maintain differentiated functions.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com