Our data also demonstrate that long-term inhibition of 11β-HSD1 in Tg2576 mice maintains cognitive performance with aging because age-matched mice without UE2316 treatment are cognitively impaired in tests performed from 16 months of age onward.
This study offers a framework for viewing NPSLE as a burden on brain function that elicits compensatory mechanisms, relying on neuronal plasticity to maintain cognitive performance.
As reviewed, multiple sclerosis patients require greater prefrontal recruitment to maintain cognitive performance relative to healthy controls (Audoin et al., 2005; Sweet et al., 2006; Forn et al., 2007).
Cognitive reserve (CR) is a newly introduced concept, which refers to performance differences in cognitive processing that make the person more likely to maintain cognitive functioning in spite of disease or damage [7].
"Maintaining physical fitness is likely to stave off cognitive decline, and maintaining cognitive fitness and activities can also help forestall physical decline," he said.
The Scaffolding Theory of Aging and Cognition (STAC) (Park and Reuter-Lorenz, 2009; Reuter-Lorenz and Park, 2014) posits that compensatory brain processes are responsible for maintaining normal cognitive performance in older adults, despite accumulation of aging-related neural damage.
While the results of cross-sectional studies show a protective effect of both fruit and vegetables for maintaining the cognitive performance [ 279– 281], the results of cohort studies suggest only a protective effect regarding vegetables.
This study aims to assess the value of treating brain metastases in patients with AJCC stage IV melanoma using adjuvant post-operative WBRT in the hope of improving disease control, and quality of life, while maintaining satisfactory cognitive performance.
Physical training has been established as a major tool for prevention of the occurrence of a range of diseases and loss of functional impairment as well as rehabilitative approaches such as maintaining autonomy, cognitive performance, and the reduction of depressive mood [ 73].
In contrast, pre-stress injected AChE-suppressing lentivirus, but not a control virus, reduced hippocampal levels of both miR-132 and AChE and maintained similar cognitive performance to that of naïve, non-stressed mice.
