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The objections usually center on the cost or maintaining closure and peace of mind for the victim's family.
A prediction of the model is that high doses of the combined stimulus 'backfire' past 45 minutes resulting in the stomata re-opening rather than maintaining closure.
The effect of adalimumab on fistula closure was durable, as demonstrated by three-quarters of the adalimumab-treated patients (NRI; 90% with observed analyses) who had healed fistulas at the end of CHARM maintaining closure following an additional year of open-label therapy.
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But to achieve and maintain closure entails solving complex ecological challenges.
In later interviews, Carey explained how during those heartfelt and emotional moments they experienced during his sickness, they were able to maintain closure for all those years of separation.
Direct interaction with the mPTP by cyclosporine modifies the calcium sensitive opening of the pore and thereby maintains closure during ischaemia [ 11, 41].
Secondly, an antioxidant response active only when both hormones (ABA and ethylene) are present simultaneously which does not allow the ROS signal to persist long enough to maintain closure, thus disrupting the closure process.
Israel locked Palestinians into their cities in the West Bank and Gaza Strip today, maintaining a closure it said would last until Wednesday morning.
Egypt too lent a hand by maintaining the closure of Gaza's one non-Israeli controlled entry/exit point to the world – the Rafah border crossing in Egyptian Sinai (it is true that Egypt was under pressure to adhere to this policy, but it is a sovereign state and makes its own choices).
Infliximab is the only other TNF antagonist shown to be effective in inducing and maintaining fistula closure.
Maintaining stomatal closure and inhibiting stomatal opening are separate processes [ 15], and require other regulatory interactions and expression of certain genes [ 83] which we do not consider here.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com