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These findings may reflect the difference between maintaining chromatin assembly functions and epigenetic marks during DNA replication versus the established role of Chd9 in regulating genes required for skeletal tissue development [58].
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This evidently requires some mechanism for maintaining chromatin integrity.
Smolle, M. et al. Chromatin remodelers Isw1 and Chd1 maintain chromatin structure during transcription by preventing histone exchange.
Grande, M. et al. Crosstalk between Nap1 protein and Cds1 checkpoint kinase to maintain chromatin integrity.
Accordingly, we propose that the 26SP limits chromatin opening by BRM in conjunction with histone hyperacetylation to maintain chromatin stability and avoid DSB formation under high-B conditions.
High mobility group box 1 (HMGB1) is a non-histone protein required to maintain chromatin architecture.
We discuss the importance of this H3.3 deposition as a salvage pathway to maintain chromatin integrity.
She summarized that the acetylation of H3K56 drives chromatin disassembly and reassembly at promoter regions, and chromatin assembly after DNA synthesis, and plays an important role in maintaining a normal life span in yeast.
We discovered that inactivation of the chromatin assembly factor Spt6 enables the PHO5 promoter to be maintained in a nucleosome-depleted state through DNA replication even when the activator that originally signaled for promoter chromatin disassembly was exported to the cytoplasm prior to DNA replication.
DOI: http://dx.doi.org/10.7554/eLife.02443.002 Chromatin assembly during DNA replication is crucial for the repackaging of newly synthesized DNA and for maintaining or erasing histone modifications.
Chromosome replication, gene expression and chromatin assembly all occur on the same template, necessitating a tight spatial and temporal coordination to maintain genomic stability.
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