Sentence examples for maintaining centromere integrity from inspiring English sources
These results suggest that Mcl1 functionally interacts with Sir2 and Clr3 HDACs in maintaining centromere integrity.
As a role for Snf2 in centromere function had not, to our knowledge been proposed previously, we next sought to investigate the role of Snf2 in maintaining centromere integrity and chromosome segregation.
An interesting study by Blasco and collaborators [40] has reported a reduction in centromeric repeats in mouse cells lacking the Dnmt3a and Dnmt3b DNA methyltransferases, suggesting DNA methylation at the centromeric heterochromatin to be an important mechanism to suppress "illicit" centromere mitotic recombination and to maintain centromere integrity.
However, the exact timing of centromeric transcription, the polymerase involved, the identity of centromeric RNAs and their precise role in maintaining native centromere integrity in human cells has been elusive.
This interpretation helps to clarify the roles of Cbf1 and the CBF3 complex in maintaining centromeres.
CENP-A loading at these centromeres is linked to replication fork stalling indicating that repair proteins may have a role to play in maintaining centromeres.
Alternatively, during the proposed centromere meiotic drive [ 25, 26], some haplotypes could be actively selected against to preserve the centromere integrity of the unique remaining cell that is available for fertilization during female meiosis II.
Our data show that centromeric transcription is an event integral to the epigenetic maintenance of centromere integrity, and discovering precisely where such motifs lie within active centromeres is an exciting avenue of research.
Targeted destruction of this centromeric RNA leads to the loss of centromere integrity and subsequent mitotic and cellular defects, which are mechanistically underpinned by the loss of HJURP and CENP-A recruitment to centromeres at eG1.
A mechanistic explanation for the observed mitotic aberrances in the centromeric transcript depleted cells could be loss of centromere integrity, driven by deficient targeting of HJURP/CENP-A complexes to centromeres.
In conclusion, we have demonstrated a functional requirement for PICH and BLM in the resolution of centromeric anaphase threads and consequently in the maintenance of centromere integrity.
