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In hydrogel scaffolds for 3D cell culture, porous structure plays a central role in maintaining cell survival by delivery of biochemical factors through the scaffolds.
The proteasome is involved in degradation of numerous proteins which regulate the cell cycle, indicating a role in controlling cell proliferation and maintaining cell survival.
Mechanistically, MEIS1 drives MPNST cell growth via the transcription factor ID1, thereby suppressing expression of the cell cycle inhibitor p27Kip and maintaining cell survival.
RELA and STAT5 proteins have specific binding sites on the Bcl-X promoter, and regulate one of the two Bcl-X isoforms, Bcl-xL, which is an anti-apoptotic protein involved in maintaining cell survival under stresses such as genotoxic drugs.
Under these conditions, autophagy is critical for maintaining cell survival.
Autophagy might be essential for maintaining cell survival that promotes the growth of tumors.
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These findings imply that MGP may play a cytoprotective role in maintaining cells' survival and inhibiting crystal retention under oxalate and crystal exposure.
The UPR maintains cell survival by limiting cell proliferation and further accumulation of unfolded or misfolded proteins in ER.
In turn trophic factors, such as bFGF, may be needed to maintain cell survival in face of this increased stress.
Nevertheless, it still remains to be clarified how BCR and BAFF-R signals act on one another and are integrated within the cell to maintain cell survival.
For example, EGFR forms a heterodimeric complex with ErbB3, which binds to and directly activates phosphatidylinositol 3-kinase and maintains cell survival through AKT-dependent mechanisms [12].
More suggestions(15)
maintaining cell identity
maintaining cell adhesion
maintaining cell motility
maintaining cell division
maintaining cell integrity
maintaining melanoma survival
maintaining macrophage survival
maintaining graft survival
maintaining cell physiology
maintaining cell surface
maintaining cell pluripotency
maintaining cell specificity
maintaining cell wall
maintaining islet survival
maintaining acinar survival
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com