Sentence examples for maintaining cell cycle from inspiring English sources
In contrast, levels of DNA replication were diminished by only ∼20% in RB-deficient p53DD cells, confirming the importance of RB in not only initiating cell cycle checkpoints while p53 is disabled, but also in maintaining cell cycle arrest.
Inhibition of MTOR suppresses geroconversion, preventing senescence, while maintaining cell cycle arrest [ 33- 44].
Therefore, we hypothesized its role in maintaining cell cycle repression in neurons.
Depletion of NS inhibits cell proliferation in both stem and cancer cells, indicating its functional importance in maintaining cell cycle progression of those cells.
This is consistent with the observation that human differentiated cone photoreceptors (but not early cone precursors) stain strongly for pRB, suggesting that pRB does not mediate the initial proliferative arrest in these cells (Lee et al, 2006), but may be important for maintaining cell cycle exit and differentiation.
Our previous work in this field indicated that retinoblastoma protein (RB) is essential to maintain cell cycle quiescence and junctional remodeling in mature adult Sertoli cells [6].
The following gene products emerged as hubs: Fos, a transcription factor involved in stress response; glucocorticoid receptor (encoded by Nr3c1), involved in stress response and inflammation; RhoA, an important signaling molecule associated with cytoskeletal remodeling; and Cdkn1b, which maintains cell cycle arrest.
In latent infection, CDK2 activity is needed to maintain cell cycle progression and to phosphorylate RB.
Such Cdc25C inactivation helps to maintain cell cycle arrest by Wee1.
Therefore Smad7, as opposed to pRb (which maintains cell cycle order), may cause a transient arrest of the cell cycle in proliferating cells.
The increase in PPP1R1A could complement the Ad E1A mediated displacement of E2F from pRb by preventing PP1 activating (dephosphorylating) pRb; this would maintain cell cycle progression.
