Sentence examples for maintaining an acidic from inspiring English sources

First, disulfide bond scrambling is prevented by blocking free thiols with N-ethylmaleimide (NEM) and by maintaining an acidic pH throughout the sample preparation process, the latter of which includes precipitating freshly prepared protein samples with trichloroacetic acid (TCA) as early as possible and carrying out all protease digestions at pH 6.5 (Fig. 1).

CA IX is one of the cell surface transmembrane carbonic anhydrases involved in maintaining an acidic extracellular pH in tumours.

In addition to maintaining an acidic proteome and a cell wall composed of acidic glycoproteins, haloalkaliphilic species appear to have evolved several other mechanisms of adaptation to their niche [ 39- 41].

This includes acting as physical barriers to keep HIV and other pathogens from reaching target cells, maintaining an acidic pH in the vagina, enhancing the natural defence mechanisms of the vaginal mucosa and stripping pathogens of their outer covering [ 11, 12].

HF acid is the main reactant with formation rocks, while HCl acid is intentionally added into the mixture to reduce HF consumption and to maintain an acidic environment, which prevents precipitations of HF reaction by-products (Al-Harthy 2008/2009).

Lamellar bodies in type II cells maintain an acidic milieu (pH ∼6.0) due to the V-ATPase activity [25], [41].

The role of CFTR in regulating bactericidal activity by macrophages was first demonstrated in 2006 in murine macrophages, this defect was observed in lung, but not peritoneal, macrophages and was related to the inability of CFTR−/− macrophages to maintain an acidic pH in the intralysosomal compartments [12].

As a result, cancers often maintain an acidic microenvironment even when vascular density and flow is relatively normal.

When a typical urinary micturition pattern was mimicked, the skin-adapted design maintained an acidic surface pH even after repeated wetting.

Vacuolar ATPases are expressed in the intracellular membranes (for example, lysosomes) of all eukaryotic cells [ 73], where they pump H+ ions inward to maintain an acidic pH.

Currently, the most widely used autophagy inhibitor is CQ, a well-known antimalarial drug in clinical use for more than 70 years., CQ functions as a freely diffusing lysosomotropic agent that enters the lysosome, is deprotonated, and becomes trapped inside as a diacidic base., By sequestering the free hydrogen ions required to maintain an acidic pH, CQ increases the basicity of the lysosome.