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The short dwell time (time spent to acquire the specific SRM/MRM transition) and fast switching of transitions in QqQ permit the simultaneous quantification of hundreds of targets while maintaining acceptable sensitivity.
The largest study to date, including 151 patients, illustrated the utility of CT imaging by incorporating whole brain Hounsfield units; a decrease in this value, especially in combination with traditional clinical features, was highly specific for predicting poor outcome while maintaining acceptable sensitivity [ 69].
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The best level of performance was taken to be that threshold similarity which resulted in the maximum values for the precision, the accuracy, the F index, the Youden index and the Matthews coefficient whilst maintaining acceptable values of the sensitivity and specificity.
The plots for different age groups were used to determine optimal cut off points which are defined as the TLC value that yields the highest sensitivity while maintaining acceptable specificity.
The challenge is to increase the sensitivity of TTs while maintaining acceptable specificity.
There is adequate evidence to speculate that targeting HIF-1α could improve the long-term prognosis of these patients In order to increase the overall sensitivity of the immunoassay, maintaining acceptable levels of specificity, a panel of antibodies should be used.
Since we noted that HIF-1α assessment can be antibody-dependent, a prudent future approach would be to use a panel of antibodies in order to increase the overall sensitivity of the immunoassay, at the same time maintaining acceptable levels of specificity as we did in our study.
We observe that techniques PCR 2 and particularly PCR 1 have very good sensitivity, respectively 98.6 and 100%, far better than the traditional techniques, IFA and culture, whilst maintaining acceptable specificity: 94.1 and 86.1%, respectively.
In fact, maintaining acceptable road, utility and school systems may well become more expensive.
Maintaining acceptable IAQ depends on the judicious use of three methods: source control, filtration, and dilution.
The most critical is maintaining acceptable response rates.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com